BBEdit

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 Most popular text editor for the Macintosh

 Author:       Barebones Software
 Homepage:     http://www.barebones.com/products/bbedit/index.shtml
 Family:       MacintoshEditorFamily
 Platform:     Mac OS/9, OS/X
 License:      Commercial

BBEdit has been around for decades and continues to be faithfully updated. It's commercialware, but, IMO, worth every penny.

regexps
pluggable syntax coloring
a Mac-like UI
all the standard indenting and brace balancing
built-in support for HTML
multi-file regexp-based search and replace
multiple clipboards
the ability to easily run chunks of text through arbitrary external scripts (Perl or whatever)
many other things I can't think of now

 Screenshot: